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Internationalisation became an important component of science parks (SPs) practices. In recent years, they have started to include, among the portfolio of their services, the support and fostering of their tenant firms’ internationalisation, such as soft-landing programmes and international immersion experiences for start-ups. Thus, the main aim of this chapter is to analyse these internationalisation practices in the light of the network and internationalisation theories. Based on an exploratory multiple case study the authors conducted in three Brazilian SPs located in the South of Brazil (Rio Grande do Sul State) – Tecnopuc in Porto Alegre, Tecnosinos in São Leopoldo and Feevale Techpark in Campo Bom. The authors provide evidences on how cohesive internal and external ties, networks as well as the level of specialisation are the key drivers of the internationalisation process of SPs and their tenant firms.